ABSTRACT
Barbara Wilson is a psychologist and researcher in neuropsychological rehabilitation from U.K. She is the founder of the Oliver Zangwill Centre, a place that has strongly contributed to the development of theoretical and technical approaches to rehabilitate cognitive and socio-emotional problems after brain injury. In this interview Barbara Wilson offers her personal perspective on the state of the art in neuropsychological rehabilitation, commenting on key topics such as the principles that guide holistic rehabilitation, the relevance of incorporating emotional problems after brain injury and the need to adopt research methodologies that are congruent with our object of study...
Subject(s)
Neuropsychology , Rehabilitation , Brain Injuries, TraumaticABSTRACT
Embryos of the Japanese medaka (Oryzias latipes) were exposed to serial concentrations of atrazine (0, 25, 50, and 100 ppm) and arsenic trioxide (0, 0.025, 0.05, 0.1 ppm) until hatching. Stasis of circulation, blood islands, titanic convulsions, tube heart and mortality were observed in atrazine-treated embryos. Each endpoint exhibited a concentration-response relationship. Only 4% of the embryos hatched in the 25 ppm, and none in the 50 and 100 ppm, probably due to cell death attributed to the embryos' inability to break from the chorion. With arsenic exposure, hatching was inversely correlated to chemical concentration: 86%, 75% and 54% for 0.025, 0.05 and 0.1 ppm, respectively. Hatching periods were also reduced from 7-13 days in controls to 7-11 days in arsenic-treated embryos. This observation was more pronounced with the 0.05 ppm concentration, showing a reduction of about 4 days. Despite this shortage in hatching time, there were no observable morphological abnormalities, as seen with atrazine. The ecological significance of these findings and implications for the development of sublethal toxicity tests using Japanese medaka embryos are important.